We agree that there is a need to qualify a variant category, but not in Observation.category as initially proposed. Instead, we propose to add a new component to CancerGeneticVariant for molecular consequence, whose values are bound to the sequence ontology "structural variant" concept ( http://www.sequenceontology.org/browser/current_release/term/SO:0001537). This representation aligns with how the HL7 Clinical Genomics Reporting IG represented qualifying variants as fusion, amplification, copy number, etc.