Background: Several Variance requests for US Core profile are because the use cases require a subject other than Patient.     Decision: Allow references to other entities for Subject/Patient elements as proposed. This will change the following profiles: 1. US Core Encounter Profile 2. US Core DiagnosticReport Profile for Report and Note Exchange 3. US Core QuestionnaireResponse Profile 4. US Core ServiceRequest Profile 5. US Core Observation Pregnancy Status Profile 6. US Core Simple Observation Profile 7. US Core MedicationDispense Profile 8. US Core Observation Clinical Result Profile 9. US Core Condition Encounter Diagnosis Profile 10. US Core Condition Problems and Health Concerns Profile 11. US Core Observation Sexual Orientation Profile 12. US Core Specimen Profile 13. US Core DocumentReference Profile 14. US Core MedicationRequest Profile 15. US Core Smoking Status Observation Profile 16. US Core Observation Occupation Profile 17. US Core DiagnosticReport Profile for Laboratory Results Reporting 18. US Core Observation Screening Assessment Profile 19. US Core CarePlan Profile 20. US Core Observation Pregnancy Intent Profile 21. US Core Procedure Profile 22. US Core Goal Profile 23. US Core CareTeam Profile 24. US Core Vital Signs Profile