New proposal for handling regions and coverage metrics: Further refine how the Genomic Study Analysis profile represents regions: The Genomic Study profile page, where it gives some highlights of the new complex extensions I introduced: https://build.fhir.org/ig/HL7/genomics-reporting/branches/kp-coverage-and-negatives/StructureDefinition-genomic-study.html The Genomic Study Analysis with new extensions for Metrics and Regions: https://build.fhir.org/ig/HL7/genomics-reporting/branches/kp-coverage-and-negatives/StructureDefinition-genomic-study-analysis.html The new 'Metrics' extension: https://build.fhir.org/ig/HL7/genomics-reporting/branches/kp-coverage-and-negatives/StructureDefinition-genomic-study-analysis-metrics.html The new 'Regions' extension: https://build.fhir.org/ig/HL7/genomics-reporting/branches/kp-coverage-and-negatives/StructureDefinition-genomic-study-analysis-regions.html A new section on 'Variant Assessment' on the 'sequencing' page (most important is the guidance for 'Pertinent Negatives' and 'No Call' and how it can have additional context from other attributes (like the new complex extension introduced here) https://build.fhir.org/ig/HL7/genomics-reporting/branches/kp-coverage-and-negatives/sequencing.html#variantassessment The GitHub PR: https://github.com/HL7/genomics-reporting/pull/84