identifier.system

• revise the manufacturedItemIdSystems value set

 type

• revise the medProductType value set

domain

• add alternative value sets as needed (e.g. SPOR)

status

• Is http://hl7.org/fhir/ValueSet/publication-status the value set to be used in this profile ?
• consider in any case to add alternative value sets as needed (e.g. SPOR). 

combinedPharmaceuticalDoseForm

• Revise the PharmaceuticalDoseForm value set
• the preferred value set should not be based on SPOR but on EDQM;
• add alternative value sets as needed (e.g. SPOR)
• evaluate if it is correct to have a single value set for the Pharmaceutical Dose Form (not sure that in all the cases the combined Pharmaceutical Dose Form applies..)

route

• revise the routeOfAdministration value set
• the preferred value set should not be based on SPOR but on EDQM;
• add alternative value sets as needed (e.g. SPOR)

legalStatusOfSupply

• revise the legalStatusOfSupply value set
• not sure that the preferred value set be based on SPOR..
• add alternative value sets as needed (e.g. SPOR)

additionalMonitoringIndicator

• Fix the additionalMonitoringIndicator value set
• add alternative value sets as needed

pediatricUseIndicator

• Fix the pediatricUseIndicator value set
• add alternative value sets as needed

classification

• add  alternative value sets as needed

marketingStatus.status

• revise the marketingStatus value set
• not sure that the preferred value set be based on SPOR..
• add alternative value sets as needed (e.g. SPOR)

packagedMedicinalProduct

• revise the packageType value set
• add as alternative value sets as needed

name.type

• should this be fixed to SPOR#220000000001 ?
• in any case check the used https://spor.ema.europa.eu/rmswi/220000000000 url, an official url is needed

name.part.type

• should this be fixed to SPOR concepts ?
• in any case check the used https://spor.ema.europa.eu/rmswi/220000000000 url, an official url is needed

usage.country

• add alternative value sets as needed

usage.jurisdiction

• add alternative value sets as needed

crossReference

• make explicit the 1.. product element, CodeableReference(MedicinalProductDefinitionUvEpi)

crossReference.type

• change the binding from extensible to preferred (in the base resource this value set is experimental / example)
• add alternative value sets as needed

operation.type.concept

• fix the operationType value set
• add alternative value sets as needed.