1) Regarding the comment: The current text leans towards disallowing the use of Questionnaire and QuestionnaireResponse in US core compatible systems. I think this is one step to far.  US  Core will not disallow using Questionnaire and QuestionnaireResponse. See FHIR-39495 further details. In addition, unchanged from version 5.0.1, the Observation profile will: a) maintain a must support Observation.derivedFrom US CoreQuestionnaire Response   b)  add an item to Observation Survey's Profile specific implementation guidance that Although both `Reference(US Core Observation Survey Profile)` or `Reference(US Core QuestionnaireResponse Profile)` are marked as MustSupport for Observation.derivedFrom, the server system are not required to support both, but  SHALL  support at least one. c)  Add a US Core v5.0.1 Patch   2) Regarding the comment: I propose that US core states that it specifies/defines the way that the results (answers) to the questionnaires who's support is required by US core are stored. This would be the Observation resources. US Core will provide the following guidance on storing responses: US Core Profile 5.0.1 6.0.0 The US Core Observation Screening Assessment Profile SHALL(US Core Observation SDOH Assessment Profile) SHALL SDC Base Questionnaire undefined SHOULD US Core QuestionnaireResponse Profile MAY SHOULD and fully documented in the Screening and Assessments page 3) Regarding the comment: US core should leave open whether the source questions and answers are stored using Questionnaire and QuestionnaireResponse resources for systems that choose to do so. We agree see 2) as well as FHIR-39495 for further details.