Autologous transplant (PBSC)

A patient diagnosed with multiple myeloma is scheduled for chemo therapy.
Prior to chemo therapy, the patient undergoes a peripheral blood stem cell (PBSC)
collection to restore their immune system post chemo therapy.
This product (PBSC) is then infused back into the patient post chemo therapy.

Patient:1
id: 1
name: The Recipient
Condition:1
id: 1
subject -> Patient:1
clinicalStatus: active
code: [multiple myeloma]
recordedDate: 2020-05-01
ServiceRequest:1
id: 1
subject -> Patient:1
status: active
intent: order
category
text: PBSC extraction
coding
system: http://www.snomed.org/
code: 387713003
display: Surgical procedure
reason -> Condition:1
occurenceDateTime: 2020-06-01
Procedure:1
id: 1
subject -> Patient:1
basedOn -> ServiceRequest:1
code: [PBSC collection]
recorded: 2020-06-01
BiologicallyDerivedProduct:1
id: 1
collection.source -> Patient:1
collection.dateTime: 2020-06-01
request -> ServiceRequest:1
Procedure:2
id: 2
subject -> Patient:1
code: [chemo therapy]
recorded: 2020-06-10
Procedure:3
id: 3
subject -> Patient:1
code: [HCT transplant]
used -> BiologiciallyDerivedProduct:1
recorded: 2020-07-10

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Allogenic transplant, multiple product (PBSC+CBU)

A patient diagnosed with acute myelogenous leukemia is scheduled for a hematopoietic cell transplantation (HCT).
The patient is typed for HLA and a search is performed for a compatible donor.
A compatible un-related donor is identified as well as a well-matched frozen cord blood unit (CBU).
The un-related donor and a sample from the CBU undergo confirmatory HLA typing and infectious disease assessment.
The patient undergoes preparative regimen prior to the HCT.
The related undergoes a bone marrow (BM) collection procedure shortly prior to the selected HCT date.
The collected BM product and the frozen CBU are transported to the center where the patient is undergoing the HCT.
The BM product and the CBU are then infused into the patient during the HCT.

Patient:1
id: 1
name: The Recipient
Condition:1
id: 1
subject -> Patient:1
clinicalStatus: active
code: [acute myelogenous leukemia]
recordedDate: 2019-03-01
ServiceRequest:1
id: 1
subject -> Patient:1
status: active
intent: order
category
text: HLA typing
coding
system: http://www.snomed.org/
code: [12345]
display: HLA typing
reason -> Condition:1
occurenceDateTime: 2019-03-10
Procedure:1
id: 1
subject -> Patient:1
basedOn -> ServiceRequest:1
code: [HLA typing]
recorded: 2019-03-10
[... other resources reflecting finding the best HLA match and confirmatory typing of selected donor]
Patient:2
id: 1
name: Unrelated Donor
ServiceRequest:2
id: 2
subject -> Patient:2
status: active
intent: order
category
text: bone marrow extraction
coding
system: http://www.snomed.org/
code: [12345]
display: bone marrow extraction
reason -> Condition:1
occurenceDateTime: 2019-04-01
Procedure:2
id: 1
subject -> Patient:2
basedOn -> ServiceRequest:2
code: [bone marrow extraction]
recorded: 2019-04-01
Organization:1
id: 1
name: Some Donor Center
Organization:2
id: 2
name: Some Cord Bank
Substance:1
id: 1
description: anti-coagulant
BiologicallyDerivedProduct:1
id: 1
identifier:
system: http://terminology.organization1.org/product_id
value: [12345]
productCode: [bone marrow]
status: available
request -> ServiceRequest:2
collection
source -> Patient:2
dateTime: 2019-04-01
processing
additive -> Substance:1
timeDateTime: 2019-04-01
BiologicallyDerivedProduct:2
id: 1
identifier
system: http://terminology.organization2.org/cbu_id
value: 989251229
collection.source -> Organization:2
collection.dateTime: 2019-04-01
request -> ServiceRequest:2
storage[1]
temperature: -200
scale: celcius
duration
start: 2015-05-01
end: 2019-04-01
Procedure:3
id: 2
subject -> Patient:1
code: [preparative regimen]
recorded: 2019-04-03
Procedure:4
id: 3
subject -> Patient:1
code: [HCT transplant]
used[1] -> BiologiciallyDerivedProduct:1
used[2] -> BiologiciallyDerivedProduct:2
recorded: 2019-04-03