add a new component to the R4 Variant profile for expressing the method of determination for variant inheritance below. •Component: variant-inheritance-basis •Short name: Evidential basis for variant inheritance •Definition: The method by which the variant inheritance is determined. •Code: LOINC 82309-6 (Basis for allelic phase) • Value binding: LOINC Answer List LL4050-2 o Directly measured o Family DNA o Family history o Inferred from population data Consistent with other places where this answer list is used (e.g., the method of Haplotype and Sequence Phase Relationship profiles), we propose making the value set extensible, not required