There's no reason to enumerate everything that's possible - the spec already does that. Also, the current sentence is confusing - the profiles do exist…

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Existing Wording:

Observation.derivedFrom should reference the SDC QuestionnaireResponse Profile and/or the SDOHCC-Observation-ScreeningResponseBase-1 Profile if they exist.

Proposed Wording:

Observation.derivedFrom should reference instances that comply with the QuestionnaireResponse (if based on a specific answer) or SDOHCC Observation profile (when derived from other observations - which are themselves typically based on questionnaire answers). However, references to other instance types are also possible.

(Comment 123 - imported by: Robert Dieterle)