Persuasive with mod Include a summary of known supported use cases on the therapeutic implication page. These will include at least:  Somatic PGx Implication of NC_000017.11:g.39723967_39723981del in breast cancer - responsive to lapatinib Implication of NM_007294.4(BRCA1):c.5578del in breast cancer - presumed responsive to olaparib+bevacizumab Somatic clinical trials Implication of NC_000010.11:g.121498525T>G in breast cancer - eligible for clinical trial NCT01234567 Germline PGx Implication of CYP2C19 *1/*2 genotype - intermediate metabolizer of clopidogrel Implication of RYR1 mutation - high risk of reaction to halogenated anesthetics Implication of SLCO1B1 *1/*14 genotype - increased transporter function with increased simvastatin exposure Implication of rs17244841 AA genotype - increased efficacy of simvastatin Implication of CYP2C19 *2/*2 AND CYP2D6 *2/*2 - poor metabolizer of amitriptyline Germline clinical trials Implication of APOE e1/e1 genotype - ineligible for clinical trial NCT03131453 Include an example of how a clinical trial match can be represented as a therapeutic implication.  Include SNOMED codes 444734003|Does not meet eligibility criteria for clinical trial (finding); 399223003|Patient eligible for clinical trial (finding) into the value set for the new 'predicted-therapeutic-implication' component. NOTE: FHIR-34277 will introduce a new extension that would allow referencing a "ResearchStudy" resource.