Details
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Type:
Change Request
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Status: Triaged (View Workflow)
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Priority:
Medium
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Resolution: Unresolved
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Specification:Genomics Reporting (FHIR)
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Raised in Version:STU3
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Work Group:Clinical Genomics
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Related Artifact(s):Observation
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Change Category:Enhancement
Description
The required "medication assessed" component needs to be able to have a recommendation proposal from the lab. Each medication assessed for a given derived pgx genotype or complex diplotype finding that has a metabolic, transporter or efficacy impact should also be able to have a text and url recommendation. Many PGX results show several drug-recommendations for a single PGX metab, efficacy or transporter impact.
For example
CYP2C19 *2/*2 may be a Poor Metabolizer for the following
1) clipidogrel - https://cpicpgx.org/guidelines/guideline-for-clopidogrel-and-cyp2c19/ - lab text abstract of interp/recommendation
2) voriconaxzole - https://cpicpgx.org/guidelines/guideline-for-voriconazole-and-cyp2c19/ - Lab text abstract of this
3) citalopram, escitalopram - https://cpicpgx.org/guidelines/guideline-for-selective-serotonin-reuptake-inhibitors-and-cyp2d6-and-cyp2c19/ - lab abstract
4)amitriptyline , etc..
...